14th Charles Rodolphe Brupbacher Symposium 2019


The following Scientific Symposium will take place at the
ETH Swiss Federal Institute of Technology, Rämistrasse 101, Audi Max (HG F 30)

The preliminary Program (to be updated)

Tuesday, January 29, 2019
19:00 - 20:00 Charles Rodolphe Brupbacher Public Lecture

                       Anne Müller: Mikrobielle Infektionen als Ursache von Krebs

Wednesday, January 30, 2019
12:00 - 13:30 Registration
13:30 - 15:00 Cancer Cell Heterogeneity
                       Chair: Lukas Sommer, Zurich

Andreas Trumpp: A single cell view on stem cells and cancer
Alain Puisieux: Cellular pliancy and breast cancer heterogeneity
Nicola Aceto: Heterogeneity and vulnerabilities of circulating tumor cells

15:00 - 15:30 Coffee break
15:30 - 17:30 Genetics and Epigenetics
                       Chair: Lauri Aaltonen, Helsinki

Peter Lichter: From (epi) genomic profiling to clinical applications
Jean-Philippe Theurillat:
Towards understanding genetically-defined subtypes of prostate cancer
Nada Jabado:
Oncohistones: how to turn the cell's symphony into non-harmonic rap
G. Steve Bova:
Evolution of lethal prostate cancer at primary and metastatic sites: Can we identiy what is important?

17.45 - 20:45 Posters, Beer and Pretzels

Thursday, January 31, 2019

08:00 - 08:30 Registration
08:30 - 10:00 Big data in Epidemiology and Cancer Research
                       Chair: Sir Alex Markham, Leeds

Richard J. Gilbertson: Multi-organ mapping of cancer origins
Ian R. Tomlinson: Inherited factors that influence cancer risk and behaviour
Serena Nik-Zainal: Insights from cancer genome sequencing: Utilising the totality of mutagenesis for clinical purposes

10:00 - 10:30 Coffee break
10:30 - 12:00 Signaling pathways in response & resistance to cancer therapy
                       Chair: Nancy Hynes, Basel

Mike Hall: Mechanisms of Evasive Resistance in HCC
Daniel S. Peeper: Towards rational combinatorial cancer treatment - a functional genomics approach
Gerhard Christofori:
Epithelial-mesenchymal cancer cell plasticity as escape route from therapy

12:00 - 13:30 Lunch + Coffee + Posters
13:30 - 15:00 Cancer metabolism/autophagy
                       Chair: Josef Jiricny, Zurich

Sean Morrison: The metabolic regulation of metastasis
Pierre Close: Translation regulation through wobble tRNA modification in cancer
Matthew Vander Heiden: Role of metabolism in supporting tumor progression

15:00 - 15:30 Coffee break
15:30 - 17:00 Tumour Microenvironment and Metastasis
                       Chair: Miriam Merad, New York

Karin de Visser: Dissecting tumor-genotype/immunophenotype relationsships in metastatic breast cancer
Johanna Joyce:
Exploring and exploiting the tumour microenvironment
Paul Frenette:
Cancer regulation by the bone marrow microenvironment

17:15 - 18:30 Award Ceremony
Charles Rodolphe Brupbacher Prize for Cancer Research 2019
Public Event

Friday, February 1, 2019

08:30 - 10:00 Breakthroughs in Cancer Therapy
                       Chair: Markus Manz, Zurich

Antoni Ribas: Overcoming PD-1 blockade resistance
Andrew W. Roberts: Targeting BCL2 as therapy for haematological malignancies: from  concept to emerging clinical applications
Peter Hillmen: Curing CLL: A glimpse into the future of cancer treatment?

10:00 - 10:30 Coffee break
10:30 - 11:30 Breakthroughs in Cancer Biology
                       Chair: Holger Moch, Zurich

Bernd Bodenmiller: Highly multiplexed analysis of tissue ecosystems using imaging mass cytometry
Nicola Valeri: Patient-derived organoids: promises, hurdles and potential clinical applications

11:30 - 12:00 Award Ceremony Young Investigator Award
Public Event

12:15 End of Meeting